Over time, it’s easy to become entrenched in how we view and move through the world. Firing up the same well-worn neural pathways becomes effortless, leading most of us to live more confined existences than we’d like to admit. For some, these ingrained habits may be a preference for a certain kind of takeout or other triviality, but for others, it can result in mood disorders or addiction.

So how hard is it to change your mind? A 2020 study published in Scientific Reports suggests a single dose of psilocybin may change your outlook on life—for good. Psilocybin is a naturally occurring psychedelic drug found in certain mushrooms. Like cannabis, psychedelics are becoming accepted and celebrated as potent plant medicine. Psilocybin may help forge new neural networks, helping individuals shake off harmful behaviors and thinking patterns.